Creatine + Training + Insulin
= THE PERFECT ANABOLIC STORM
Years of study by top human performance researchers has confirmed that insulin is one of the body’s most powerful musclebuilding hormones. In fact, research published in the Journal of Clinical Investigation found that insulin is so potent it could support protein synthesis in skeletal muscle1! Insulin is also very anti-catabolic and reduces protein degradation and stimulates cellular hydration – causing water retention within the muscle cells that translates into greater protein synthesis.
Early creatine researchers also knew the power of insulin, and in some of the first research published in the American Journal of Physiology, it was discovered that taking creatine along with a high dose of simple carbohydrates could trigger as much as 60% better creatine storage in the muscles2. Researchers reporting on their findings confirmed that insulin was the key to pushing more creatine through muscle cell membranes.*
The purpose of insulin in the body is to regulate blood glucose levels. When an elevation of blood glucose occurs, the beta cells of the pancreas secrete insulin into the portal vein (the “spike”). Ultimately, insulin works by triggering the movement of nutrients from the blood to the cells – fortifying your muscles with the ingredients they need to grow while at the same time normalizing your blood glucose levels.
Insulin needs to attach itself to receptors in order to have any effect. This is what determines how much of the glucose, amino acids and creatine in your blood are taken up by the cell transporters. In your muscle cells, there are two glucose transporters: GLUT-1 and GLUT-4. However, it’s the GLUT-4 receptors that are predominant in adult human muscles, and they play an important role.
GLUT-4 transporters migrate from the cytoplasm right to the cell surface in response to insulin and muscle contraction (lifting weights). Yes, training can actually increase the ability of your muscles to take in more nutrients because training increases the number of available receptors on the muscle membrane. The more available receptors there are, the more glucose, amino acids and creatine can be absorbed from the blood.*
This, in essence, creates the perfect anabolic storm – an optimal environment where insulin-sensitive muscle cells are able to quickly utilize anabolic nutrients like creatine, amino acids and glucose – priming them for incredible strength and massive muscular growth!*